The "I Hate the Antichrist" meme originates from a panel in the webcomic "The Perry Bible Fellowship" by Nicholas Gurewitch. In the comic, a child is holding a note reading "I hate the Antichrist" and crying while a teacher reacts with apparent horror. This image is used humorously to express exaggerated or misplaced anger towards something trivial or unexpected. The meme format typically involves modifying the text on the note to suit various contexts, often highlighting absurd or petty grievances. Its blend of dark humor and surrealism makes it a versatile and popular meme for conveying exaggerated disdain or frustration.